The Department of Neurosurgery constitutes the largest specialty division for neurological surgery in the Rohilkhand region, and is the most reputed of its kind in Western Uttar Pradesh. It is the main tertiary level center of the region for neurotrauma and neurosurgical maladies. The philosophy of working in unison with other specialty divisions of Neuromedicine, General surgery, Orthopaedics, Radiodiagnosis, Otorhinology and Physical medicine to offer multidisciplinary approach to problem solving, lies at the core of the department's work ethos. The department handles all kinds of trauma cases, cerebrovascular accidents, tumors, spinal deformities/lesions and pediatric neurological diseases.

Trans sphenoidal endoscopic surgery, minimally invasive spine surgery for pituitary tumor, cranial endoscopic surgery, intervention for aneurysm, multi-level spinal surgery are example of few high end surgeries that are being routinely done here.